VENTRI BIOLOGICALS ( Vhpl) Conducts Technical Seminar On Newcastle Disease Control

Ventri Biologicals, vaccine division of VH Group , organized technical seminar in Chandigarh and Bangluru on 1st April'2015 and 3rd April'2015 respectively, aiming to extend it's technical expertise in Newcastle disease control in India, in relation to Asia and world situation.

The seminar was arranged at the Hotel KC Cross Road, Panchkula . The seminar was attended by top poultry consultants, VH Group veterinarians from various divisions like PDDL, Panchkula( Dr. Rakesh Gupta & his team) ; Breeder Technical Service team ( Dr. Rohilla and his team ) ; Layer technical service team ( Dr. Kadam & his team); CBF division ( Mr. S. S.Lakra & team); Broiler Parent Division ( Dr.Danveer and his team) and service products teamof North Zone ( Mr. Raju Tanna, Mr. Sourabh Gupta, Mr. Shishi bhushan and their teams).

The seminar was also arranged at the Hotel Regalis, Bangluru. The seminar was attended by VENCO technical team ( Dr. Harsh Shetty and his team) ; PDDL- Bangluru ( Dr. Kiran's team).

The meetings were also attended by Dr. Ganesh Darban, Sr. Product Manager ; Dr. Sanjay Gavkare, GM-Technicaland Mr.Deepak Khosla, GM-MKTG.

Mr. H. S. Padda , DGM , Venky's India Ltd. welcomed the guests and peakers at Chandigarh and Dr. N. Baburaj, AGM, Venky's India Ltd. welcomed the guests and speaker at Bangluru.

Dr. Sanjay Gavkare and Mr. Deepak Khosla gave brief introduction of Dr. Karel A. Schat. He introduced Dr. Karel Schat and referred his association with Indian Poultry Industry since year 1996. He is Professor Emeritus, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. He received his PhD degree from Cornell University in 1978 under the guidance of Dr. Bruce Calnek. He received training in Marek's disease virology from Dr.Bart Rispens at the Dutch Central Veterinary Institute. He retired in 2011 as a Professor in Avian Virology and Immunology. He is well known for isolating the SB-1 vaccine strain of Marek's disease and research on the pathogenesis and immunology of Marek's disease. In addition he has contributed significant new knowledge of chicken anemia virus, rotaviruses and more recently on Mycoplasma gallisepticum infections in house finches and avian influenza. Ton has published over 172 papers in peer-reviewed journals and more than 35 book chapters. He also served as co-editor of the first and second editions of Avian Immunology. In 2010 he was recognized by his peers with a special award for outstanding research in the field of Marek's disease and he was inducted in the Hall of Honour of the World Veterinary Poultry Association in 2013.

The agenda of the Newcastle disease control seminar series addressed several questions raised by technical s e r v i c e managers and consultants for the control of Newcastle disease by Dr. S a n j a y Gavkare , GM- Te c h n i c a l , V e n t r i Biologicals a n d b y D r. Karel Schat , the subject m a t t e r specialist of Ventri Biologicals.

1) Is Newcastle disease ( ND ) currently problem ?
Yes, Newcastle disease is still a problem in India when compared to the other countries.

2) Is ND frequently diagnosed?
Yes, ND is frequently diagnosed in many countries after year 2000. India, Pakistan, Indonesia, USA , Mexico, Argentina, China, Kajakstan, Egypt , Sudan are major countries.

3) What are the serotypes responsible for Newcastle disease outbreaks?
ND is caused by family of Avian Paramyxoviruses ( APMV) . There are currently 11 different serotypes. Serotype 1 infects chickens and many other species of birds. The other serotypes are not important for chickens.

4) Schematic diagram of Newcastle disease virus structure

5) What are the Virulence determinants of APMV-1 ?
F protein is an important virulence factor and used for classification Non-structural V protein interferes with host interferon responses and prevent apoptosis thus allowing virus replication to proceed The replication complex (NP/P/L) is also important for the virulence .

6) Whether the ND viruses can be classified based on virulence?

7) How many of APMV-1 , Class-II Genotypes are prevalent worldwide :
They are classified into two classes . Class II AMPV -1 strains have more than 15 genotypes identified ( 2012) which causes ND outbreaks in more than 236 avian species from mild to severe form.

8) Any considerable antigenic drift observed over time in Serotype-1 :
Miller et al (2010) observed 10 genotypes + several subtypes , whereas he observed 19genotypes + several subtypes in year 2015 which reflect true genetic drift or more isolates are sequenced. He demonstrated worldwide distribution of these 10 genotype over last 75 years.

9) What are the recent publications from India ?
In India, Bhuvaneswari et al. 2014; Moria et al. 2014; and Gogoi et al. 2015 has demonstrated genotype VII in LaSota vaccinated chickens. Where as unpublished data from India provided by reputed poultry labs in India confirmed prevalence of genotype VIIb.

10) What is the genotype prevalence in neighboring country, Pakistan ?
In Pakistan, subtype VIIf is widely circulating in Pakistan replacing XIII (Siddique et al, Virology 44:37-40, 2 0 1 3 ) . R e c e n t l y, genotype VIIi is detected in most of the NDV outbreaks ( Rhamani et al. J. Clin Microbiol In pres posted on line 2-18-2015).

11) Whether LaSota vaccination via drinking water or eye drop route is effective in growers or layers ?
Yes, it is. LaSota vaccination does not get neutralized by circulating IgY antibodies when applied via drinking water or eye drop.

12) Which type of vaccine offers protection against morbidity and mortality?
The Inactivated vaccines if scheduled properly in combination with available live vaccines can offer best protection against mortality.

13) Whether conventional vaccines produce sterilizing immunity?
No. They do protect against mortality but does not stop shedding of challenge virus from vaccinated birds.

14) Why do vaccination breaks occur in- spite of good quality vaccines?
"Live vaccines are thermolabile, poor cold chain reduces titer and is found true with imported companies. "Poor biosecurity : vaccines do not protect when there is no or poor biosecurity "Incomplete vaccination: not all birds receive the correct dose of the vaccine causing low flock immunity ( below 85%). "Lastly, the damaged immune system due to infection with CAV and or IBDV or mycotoxins or stress or a combination of these factors

15) Are there any attempts to produce recombinant live vaccines ever?
Yes. There were attempts to generate recombinant LaSota replacing HN + F of LaSota with HN + F of PK33 (genotype XIII) (rLS- PK33), by Cardenas-Garcia et al. Biologicals 43:136-145, 2015 This live recombinant vaccine offered sterilizing immunity in chickens.

16) What are the benefits of vaccination with genotype specific inactivated vaccines?
The vaccination with genotype specific Inactivated vaccines is found advantageous with respect to seroconversion and prevention of virus shedding when challenged with homologous genotypes. This was demonstrated by Miller et al. Develop Comp Immun 41:505-513, 2013.

17) Whether Genotype specific vaccines have impact on protective immunity?
Yes. It is proven by many scientists and the few commercial vaccine manufacturers do have licensed products which were found highly beneficial for the poultry industry.

18) What vaccine design should India plan to control Newcastle disease?
Indian poultry industry should plan new vaccine with high purity antigen, high quality vehicle, genotype-match Inactivated vaccine which can be scheduled to get sterilizing immunity.

Conclusively, it was agreed by all consultants that ---
"Good vaccination practices are essential to obtain a high level of antibodies in as close to 100% of the birds as possible (FLOCK immunity).

"BIOSECURITY remains paramount for good protection.

Continuous monitoring for geno(sub)types is important.

The vote of thanks was given by Mr. Navin Sehgal, AGM, at Chandigarh and Mr. Manjunath, ZM, at Bangluru.

Please contact for details : Dr. Ganesh Darban.Sr. Product Manager - Ventri Biologicals ( VHPL)

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